Divide and conquer

Build a virtual wall between your business activities and your personal digital life. Use separate email accounts, separate email clients or browser windows for each.

If you use you business systems for personal use - and working at home, it's sometimes hard not to - then create separate directories/folders, use multiple browsers (one for work, one for personal).

If your computer supports virtual desktops/windows, use those. Create some desktops for work, and some for personal use. All major operating systems support some type of virtual desktops. I use 12 on my Mac.